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Now, let's talk about the **_human epidermal growth factor receptor 2 (HER2)_**, which is quite different from ER and PR. HER2 is a protein that sits on the surface of breast cancer cells and controls how they grow, divide, and repair themselves. Unlike ER and PR, HER2 is not influenced by hormones; instead, it's a growth factor receptor. In about 20% of breast cancers, the cells have too many copies of the HER2 gene, or they produce too much HER2 protein. When this happens, the cancer cells grow and divide at a much faster rate, making the cancer more aggressive. When a patient is diagnosed with HER2-positive breast cancer, it means the cancer cells have high levels of HER2 protein. This is determined through a test during the biopsy, and it plays a vital role in determining treatment strategies. Thankfully, there are several targeted therapies available that specifically target HER2. These treatments, such as trastuzumab (Herceptin), pertuzumab (Perjeta), and others, work by either blocking the HER2 protein directly or interfering with its ability to send signals that promote cancer growth. These medications are often used in combination with other treatments like chemotherapy, improving the chances of stopping the cancer from spreading and significantly improving patient outcomes. The discovery of HER2-targeted therapies has revolutionized the treatment of HER2-positive breast cancer. These therapies have made a huge difference in patient survival rates. HER2-positive breast cancer used to be associated with a poorer prognosis, but with these advanced therapies, the outlook is now much more positive. The development of HER2-targeted treatments is a testament to the power of precision medicine, where treatments are designed to target the specific characteristics of the cancer cells. It allows doctors to tailor treatments that are more effective and have fewer side effects compared to traditional methods. Understanding the role of HER2 receptors has not only helped in identifying effective treatments but has also improved the accuracy of breast cancer diagnosis, allowing for a more personalized approach to patient care.
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Conclusion Obstructive sleep apnoea meaning
* **Emergency Management:** Encompasses the planning, preparation, response, and recovery activities undertaken to mitigate the impact of emergencies. This involves identifying potential hazards, developing emergency plans, training personnel, and coordinating resources.
